How Should We Classify Psychopathology?
Nosology: compare DSM and ICD with HiTOP, RDoC and symptom networks, and ask what makes a classification useful.
- Level
- Intermediate
- Reading load
- 11 core readings in 5 units
- Prerequisites
- What Is a Mental Disorder? provides the recommended foundation in definitions, validity, categories and dimensions. Some familiarity with association, measurement and study design. The guides introduce the statistical terms needed for comparison.
- Last reviewed
- September 2026
Introduction
Classification brings order to difficulty, but the order depends partly on its purpose. Communicating clearly, understanding causes, anticipating outcomes, and deciding about care may favor different arrangements. Nosology, the study and organization of disease classifications, asks how these arrangements are built and tested. What does a system help us understand or do, and which distinctions might it obscure?
Building on What Is a Mental Disorder?, this path compares approaches to classification. It begins with purposes and boundaries, then examines the clinical systems known as DSM, the Diagnostic and Statistical Manual of Mental Disorders, and ICD, the International Classification of Diseases. How do definitions become guidance that clinicians can apply, and what would show that revised guidance is useful?
A dedicated unit considers the Hierarchical Taxonomy of Psychopathology, or HiTOP. It starts from patterns in which symptoms and other features occur together, organizing narrower dimensions within broader ones. The readings examine proposals for clinical use, a comparison with DSM diagnoses over time, and the interpretation of a broad factor summarizing shared variation across difficulties. Organizing that variation raises different questions from explaining its causes.
The next unit turns toward mechanisms. Research Domain Criteria, or RDoC, organizes research around functional systems and different kinds of evidence. Symptom-network approaches instead examine how difficulties might relate to one another. The closing studies return to assessment in practice, including how clinicians use guidance and how patients' cultural contexts enter the encounter.
By the end, you should be able to explain the question each framework addresses, distinguish descriptive structure from a causal explanation or prediction, and propose a fair evaluation for a specified use. The aim is to compare the work these systems can do, rather than choose a winner independently of purpose.
Unit 1 of 5
What is a classification for?
Begin with two different questions: how a system acquires its categories, and what those categories are good for. Historical choices shape the starting point. A distinction between validity and utility helps explain why an imperfect classification may still be informative—and why usefulness does not settle what exists in nature.
Reading
1 of 11An Historical Framework for Psychiatric Nosology
Kendler, K. S. (2009). An historical framework for psychiatric nosology. Psychological Medicine, 39(12), 1935–1941. https://doi.org/10.1017/s0033291709005753
Foundational argument · Critical reappraisal · Moderate · Full work: 7 pages
Follow the analogy between biological taxonomy and psychiatric revision, including its limits.
Why you’re reading it. Make the history and revisability of classifications explicit before comparing current approaches.
A question to consider. If two teams repeatedly revise different starting classifications using different validators, what would they need to agree on before convergence became meaningful?
Reading
2 of 11Distinguishing Validity From Utility
Kendell, R., & Jablensky, A. (2003). Distinguishing between the validity and utility of psychiatric diagnoses. American Journal of Psychiatry, 160(1), 4–12. https://doi.org/10.1176/appi.ajp.160.1.4
Foundational argument · Critical reappraisal · Moderate · Full work: 9 pages
Keep claims about natural boundaries separate from claims about a useful decision aid.
Why you’re reading it. Establish the evaluation criteria that will recur throughout the path.
A question to consider. A category predicts service needs but has no clear boundary from neighboring presentations. How would you evaluate it under each of the authors’ two concepts?
Unit 2 of 5
How are boundaries turned into diagnostic guidance?
A manual must translate concepts into descriptions that can be used. First and colleagues explain how ICD-11 guidance was being constructed. Fried and Nesse then expose diversity within one diagnosis. These contributions connect design choices with a concrete problem; they do not imply that every diagnostic system is equally rigid or entirely categorical.
Reading
3 of 11Developing the ICD-11 Diagnostic Guidelines
First, M. B., Reed, G. M., Hyman, S. E., & Saxena, S. (2015). The development of the ICD-11 Clinical Descriptions and Diagnostic Guidelines for Mental and Behavioural Disorders. World Psychiatry, 14(1), 82–90. https://doi.org/10.1002/wps.20189
Methodological contribution · Moderate · Full work: 9 pages
Examine the proposed treatment of essential features, normal variation and nearby diagnoses.
Why you’re reading it. Connect the previous unit’s purposes to the design of usable guidance.
A question to consider. How could replacing an exact threshold with a contextual judgment improve usefulness while creating a new reliability problem?
Reading
4 of 11How Diverse Are Depression Symptom Patterns?
Fried, E. I., & Nesse, R. M. (2015). Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study. Journal of Affective Disorders, 172, 96–102. https://doi.org/10.1016/j.jad.2014.10.010
Critical reappraisal · Methodological contribution · Moderate · Full work: 7 pages
Track how the measurement choices create the symptom profiles being counted.
Why you’re reading it. Use empirical heterogeneity to ask what information a broad diagnostic category retains and loses.
A question to consider. Two people share a diagnosis but few measured symptoms. What would that observation establish about the category, and what causal conclusion would require additional evidence?
Unit 3 of 5
How does HiTOP organize psychopathology, and what does the hierarchy add?
HiTOP is the central worked comparison in this path. Begin with its nested dimensions and proposed clinical use, then examine a longitudinal test of information added to DSM diagnoses. Finish with a brief challenge to interpreting the broadest statistical factors. A hierarchy can be useful without supplying a causal explanation; a critique of the p factor is not a verdict on every HiTOP level.
Reading
5 of 11HiTOP in Clinical Practice
Ruggero, C. J., Kotov, R., Hopwood, C. J., First, M., Clark, L. A., Skodol, A. E., Mullins-Sweatt, S. N., Patrick, C. J., Bach, B., Cicero, D. C., Docherty, A., Simms, L. J., Bagby, R. M., Krueger, R. F., Callahan, J. L., Chmielewski, M., Conway, C. C., De Clercq, B., Dornbach-Bender, A., … Zimmermann, J. (2019). Integrating the Hierarchical Taxonomy of Psychopathology (HiTOP) into clinical practice. Journal of Consulting and Clinical Psychology, 87(12), 1069–1084. https://doi.org/10.1037/ccp0000452
Major synthesis · Methodological contribution · Moderate · Full work: 16 pages
Move between narrow components, broader spectra and the illustrative clinical profile.
Why you’re reading it. Learn how HiTOP addresses overlap and diversity while retaining several levels of description.
A question to consider. Using an invented presentation involving low mood, worry and withdrawal, what might a dimensional profile show that a single category omits, and what practical decision would still need a threshold?
Reading
6 of 11Do HiTOP Dimensions Add to DSM Prognosis?
Martin, E. A., Jonas, K. G., Lian, W., Foti, D., Donaldson, K. R., Bromet, E. J., & Kotov, R. (2021). Predicting long-term outcomes in first-admission psychosis: Does the Hierarchical Taxonomy of Psychopathology aid DSM in prognostication? Schizophrenia Bulletin, 47(5), 1331–1341. https://doi.org/10.1093/schbul/sbab043
Methodological contribution · Challenging · Full work: 11 pages
Compare what the diagnostic and dimensional predictor sets contain and what each adds.
Why you’re reading it. Evaluate a substantive empirical test after the implementation proposal.
A question to consider. Does better prediction of one twenty-year outcome establish that clinicians should replace DSM diagnoses with HiTOP? Specify what this study does and does not test.
Reading
7 of 11What Does a General Psychopathology Factor Mean?
Fried, E. I., Greene, A. L., & Eaton, N. R. (2021). The p factor is the sum of its parts, for now. World Psychiatry, 20(1), 69–70. https://doi.org/10.1002/wps.20814
Critical reappraisal · Methodological contribution · Moderate · Full work: 2 pages
Separate the similarity of calculated scores from an explanation of their origin.
Why you’re reading it. Prevent the hierarchy’s broadest summary from silently becoming a demonstrated common cause.
A question to consider. If a general factor closely matches a sum of diagnoses, which HiTOP claims would this challenge directly, and which would remain open?
Unit 4 of 5
Can mechanisms reorganize the field?
Classification and explanation need not develop in the same order. RDoC organizes research around processes and multiple kinds of measurement; network accounts propose interactions among problems. Compare what each framework asks researchers to observe and what would be needed to establish a mechanism. Neither is interchangeable with HiTOP’s descriptive hierarchy or an implemented clinical manual.
Reading
8 of 11Revisiting the Seven Pillars of RDoC
Morris, S. E., Sanislow, C. A., Pacheco, J., Vaidyanathan, U., Gordon, J. A., & Cuthbert, B. N. (2022). Revisiting the seven pillars of RDoC. BMC Medicine, 20(1), Article 220. https://doi.org/10.1186/s12916-022-02414-0
Major synthesis · Contemporary update · Moderate · Full work: 11 pages
Follow the framework’s updated remit, including development, environment and diagnostic sampling.
Why you’re reading it. Contrast a process-oriented research strategy with HiTOP’s organization of observed covariation.
A question to consider. For the low-mood and worry example, how would an RDoC study choose participants and measurements differently from a study comparing diagnostic groups?
Reading
9 of 11The Network Approach: Theory, Methods and Evidence
Robinaugh, D. J., Hoekstra, R. H. A., Toner, E. R., & Borsboom, D. (2020). The network approach to psychopathology: A review of the literature 2008–2018 and an agenda for future research. Psychological Medicine, 50(3), 353–366. https://doi.org/10.1017/s0033291719003404
Major synthesis · Critical reappraisal · Challenging · Full work: 14 pages
Distinguish a theory of interacting problems from an estimated network of associations.
Why you’re reading it. Ask what a causal account would add to the structural and predictive evidence already considered.
A question to consider. Draw two explanations for the same association between poor sleep and worry: direct influence and a shared cause. What observations could help distinguish them?
Unit 5 of 5
What would justify changing clinical practice?
Return to the difference between a compelling proposal and evidence about its use. One study randomizes the guidelines clinicians receive for constructed cases; another investigates a cultural interview in selected clinical settings. Compare intended diagnostic decisions, participant experience and patient outcomes. These are complementary evaluation targets, not synonyms for validity.
Reading
10 of 11Classifying Irritability and Oppositionality in Youth
Evans, S. C., Roberts, M. C., Keeley, J. W., Rebello, T. J., de la Peña, F., Lochman, J. E., Burke, J. D., Fite, P. J., Ezpeleta, L., Matthys, W., Youngstrom, E. A., Matsumoto, C., Andrews, H. F., Medina-Mora, M. E., Ayuso‐Mateos, J. L., Khoury, B., Kulygina, M., Robles, R., Sharan, P., … Reed, G. M. (2021). Diagnostic classification of irritability and oppositionality in youth: A global field study comparing ICD-11 with ICD-10 and DSM-5. Journal of Child Psychology and Psychiatry, 62(3), 303–312. https://doi.org/10.1111/jcpp.13244
Methodological contribution · Moderate · Full work: 10 pages
Keep the system-specific intended answers and individual vignette contrasts visible.
Why you’re reading it. Test what an actual comparison of classification guidance can establish.
A question to consider. How would you adapt this design to compare a HiTOP profile with existing guidance, and what independent outcome would avoid defining success as agreement with either system?
Reading
11 of 11Evaluating the Cultural Formulation Interview
Lewis-Fernández, R., Aggarwal, N. K., Lam, P. C., Galfalvy, H., Weiss, M. G., Kirmayer, L. J., Paralikar, V., Deshpande, S. N., Díaz, E., Nicasio, A. V., Boiler, M., Alarcón, R. D., Rohlof, H., Groen, S., van Dijk, R. C. J., Jadhav, S., Sarmukaddam, S., Ndetei, D., Scalco, M. Z., … Vega-Dienstmaier, J. M. (2017). Feasibility, acceptability and clinical utility of the Cultural Formulation Interview: Mixed-methods results from the DSM-5 international field trial. British Journal of Psychiatry, 210(4), 290–297. https://doi.org/10.1192/bjp.bp.116.193862
Methodological contribution · Moderate · Full work: 8 pages
Read patient and clinician judgments alongside recruitment and measurement limitations.
Why you’re reading it. Bring meaning, context and whose experience counts into the final evaluation.
A question to consider. If a new classification improved prediction but made people’s own explanations harder to express, what additional evidence and stakeholder input should enter the adoption decision?
Scope and omissions
This is a comparative nosology path, not a diagnostic manual tutorial or a survey of every proposed classification. It assumes the introductory discussion of what constitutes disorder and concentrates on construction, evidence and use. DSM and ICD are not treated as identical, wholly categorical, or unchanged over time.
HiTOP receives sustained attention without being presented as a settled replacement for every purpose. The selected longitudinal study covers one psychosis-spectrum application; the p-factor critique addresses a particular interpretation. RDoC and networks are research approaches with different aims. The path does not attempt advanced factor-model estimation, a comprehensive history of psychiatry, or a complete review of contemporary implementation evidence.
International field studies broaden the settings represented but do not establish universal applicability. Lived experience, policy consequences and cultural validity deserve more extensive study than these examples can provide. Historical and developer-authored papers are identified so their claims can be evaluated in context.
Synthesis
A classification earns support for a particular purpose. Historical coherence, repeatable decisions, natural boundaries, prediction, and usefulness place different demands upon it. Diversity within a category may reveal lost information without revealing its causes; usefulness can coexist with uncertainty about the entities a label describes. A fair comparison makes these criteria explicit and asks which evidence bears upon each.
HiTOP makes several levels of description available and invites empirical comparison. Its psychosis study illustrates how dimensional and diagnostic information can complement one another. Neither a useful hierarchy nor a broad factor automatically explains how difficulties arise. RDoC and networks sharpen mechanistic questions, while the field studies show that usable guidance and meaningful assessment require evidence of their own.
Choose a classification problem, such as overlapping mood and anxiety presentations. Compare HiTOP with one other approach. Specify the information each retains or loses, a practical threshold each would require, and two criteria for judging the comparison. Propose a study with an outcome independent of either system’s own definitions. How would you separate predictive performance from causal explanation and beneficial use? Include whose experience might be excluded and what result would change your position.
For a closer look at the processes a classification might help investigate, continue with How Do Psychological Disorders Develop and Persist?. To examine what supports a measurement claim, follow How Do We Know What a Psychological Test Measures?.
Further reading
Optional. Not part of the core sequence.
- Reed, G. M., First, M. B., Kogan, C. S., Hyman, S. E., Gureje, O., Gaebel, W., Maj, M., Stein, D. J., Maercker, A., Tyrer, P., Claudino, A., Garralda, E., Salvador‐Carulla, L., Ray, R., Saunders, J. B., Dua, T., Poznyak, V., Medina‐Mora, M. E., Pike, K. M., … Saxena, S. (2019). Innovations and changes in the ICD-11 classification of mental, behavioural and neurodevelopmental disorders. World Psychiatry, 18(1), 3–19. Paper. Extend the development account to an overview of specific changes. Treat this 2019 contribution as historical context for the later published guidance.
- Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Medicine, 11(1), Article 126. Paper. Compare the original formulation with Morris and colleagues’ update, identifying which commitments persist and which descriptions have changed.
- Kogan, C. S., Maj, M., Rebello, T. J., Keeley, J. W., Kulygina, M., Matsumoto, C., Robles, R., Huang, J., Zhong, N., Chakrabarti, S., Figueira, M. L., Stein, D. J., Strakowski, S. M., Garcia-Pacheco, J. A., Burns, S., Montoya, M., Andrade, L., Ayuso-Mateos, J. L., Arango, I., … Reed, G. M. (2021). A global field study of the international classification of diseases (ICD-11) mood disorders clinical descriptions and diagnostic guidelines. Journal of Affective Disorders, 295, 1138–1150. Paper. Extend the field-study comparison to mood disorders and consider how results depend on the particular diagnostic distinction being tested.
- Balling, C. E., South, S. C., Lynam, D. R., & Samuel, D. B. (2023). Clinician perception of the clinical utility of the Hierarchical Taxonomy of Psychopathology (HiTOP) system. Clinical Psychological Science, 11(6), 1108–1121. Paper. Add clinicians’ perceptions to the HiTOP evaluation. Ask how perceived usefulness differs from predictive evidence and from demonstrated improvement in patient outcomes.
- Haeffel, G. J., Jeronimus, B. F., Fisher, A. J., Kaiser, B. N., Weaver, L. J., Vargas, I., Goodson, J. T., Soyster, P. D., & Lu, W. (2022). The Hierarchical Taxonomy of Psychopathology (HiTOP) is not an improvement over the DSM. Clinical Psychological Science, 10(2), 285–290. Paper. Examine an explicit challenge to HiTOP. Identify the criteria used to judge improvement and formulate a fair empirical test of one disputed claim.
- Kotov, R., Krueger, R. F., Watson, D., Cicero, D. C., Conway, C. C., DeYoung, C. G., Eaton, N. R., Forbes, M. K., Hallquist, M. N., Latzman, R. D., Mullins-Sweatt, S. N., Ruggero, C. J., Simms, L. J., Waldman, I. D., Waszczuk, M. A., & Wright, A. G. C. (2021). The Hierarchical Taxonomy of Psychopathology (HiTOP): A quantitative nosology based on consensus of evidence. Annual Review of Clinical Psychology, 17(1), 83–108. Paper. Explore a longer synthesis of the hierarchy and its evidential basis. Separate evidence about organization from evidence about causes and clinical implementation.